A double-blind, placebo-controlled trial showed that a six-month nightly treatment of women aged 45–54 with melatonin (3 mg, per os) was able to normalize the turnover of bone cells, measured as the trend downward over time toward 1:1 of the ratio between N-telopeptide of Type I Collagen and osteocalcin (NTX/OC), and improve physical domain scores, without effects, however, on vasomotor, psychosocial, or sexual Menopause-Specific Quality of Life-Intervention domain scores. Here, BGLAP is linked to menopause.