CFTR and cystic fibrosis: A recent study by Phuan and colleagues [16], showed I1234-R1239del-CFTR functional rescue by TRIKAFTATM in I1234-R1239del-CFTR expressing Fisher Rat Thyroid (FRT) cells, gene-edited Human Bronchial Epithelial (HBE) cells expressing I1234-R1239del-CFTR and in primary nasal cultures from sibling CF donors bearing I1234-R1239del/W1282X mutations.