CFTR and cystic fibrosis: While the novel AC1/AC2-2/AP2 CFTR modulator combination showed the best function in I1234_R1239del/W1282X-CFTR nasal cells, the improvement for these heterozygous cells was only ~50% of the mean forskolin response (Figure 3B) and ~30% of the mean CFTRInh-172 response observed in non-CF cultures (Figure 3C).