Among those transcripts/proteins displaying the strongest discordant expression with high protein but low transcript LFC in grade III tumours were the Na+/HCO3- co-transporter SLC4A4, previously shown to contribute to the proliferation, migration and invasion of a breast cancer cell line [58], and the phosphofurin acidic cluster sorting protein-1, PACS1, recently revealed to function in the nucleus as an epigenetic regulator to promote oncogenic replication and progression [58,59]. The gene discussed is SLC4A4; the disease is breast cancer.