In addition to the established association of meningioma with pathogenic aberrations in the tumour suppressor gene NF2, genomic analyses have identified genes including TRAF7, KLF4, AKT1, SMO, PIK3CA and POLR2A to possess recurrent mutations in low grade non-NF2 mutant meningioma [6,7,8,9]. The gene discussed is KLF4; the disease is meningioma.