Given the fact that TSPAN1 inhibition sensitized both parental and the CDDP-resistant derivatives of JHU029, HTB-43 and CCL-138 cells to dasatinib (Figure S3), we wonder whether phosphorylation of SRC kinase (p-SRC or active SRC), a direct target of dasatinib, could be a mediator of TSPAN1 function in our HNSCC models. The gene discussed is TSPAN1; the disease is head and neck squamous cell carcinoma.