MKI67 and Familial prostate cancer: COX-2 and Ki-67 antigen co-expression in 42.9% and 67% of the prostate cancer patients [113].Patients with PSA > 7 ng/mL and high COX-2 expression had the highest probability of recurrence [114]. The expressions of COX-2 and E-cadherin are very firmly and inversely correlated as prognostic indicators. [115]. High expression of COX-2, TGF-beta, and Ki67 in metastatic primary prostate carcinoma was associated with death from prostate carcinoma [116].