MYCN and posterior cortical atrophy: We propose that 70812 blocks proliferation and growth of PCa and NEPC cells by interfering with N-Myc-Max interaction with DNA E-boxes through its N′-phenylbenzohydrazide scaffold, with AURKA’s kinase activity by blocking ATP from binding to its hinge region through its aminopyrazole-pyrimidine ATP-mimetic scaffold, and with AURKA’s ability to interact with N-Myc to stabilize it into an active form.