Additionally, CAFs play an important role in tumor angiogenesis, proliferation and invasion, as they produce autocrine and paracrine regulatory factors with tumor-promoting functions, e.g., vascular-endothelial growth factor (VEGF) and stromal-derived factor-1 (SDF1) stimulate the recruitment of endothelial cells [37,38]. This evidence concerns the gene CXCL12 and neoplasm.