The absence of an anti-T2 effect and impact on the late asthmatic response in this study contrast with those of previous studies with GSK2245035 in allergic rhinitis by Ellis et al. [13], and those by Leaker et al., assessing AZD8848 (another TLR7 agonist) in allergic asthma [20,24]. This evidence concerns the gene TLR7 and allergic asthma.