Perturbation Analyses has shown that a positive constant input applied to the subpopulation of SOM+ interneurons can bifurcate the limit cycle (oscillating epilepsy-like activity) to an equilibrium point (background activity), while a positive constant input on the subpopulations of pyramidal cells and PV+ interneurons preserve bursting and high frequency oscillations (Fig 5). Here, GRHL3 is linked to epilepsy.