In terms of PPIs, the above pairs of genes are still connected, and we retrieved a triple formed by ICAM1, RAVER1 and TYK2, and the pair KRI1-MRPL4 that is associated with sun exposure, a well-established beneficial factor for psoriasis and Crohn’s disease (Jantchou et al., 2014; Søyland et al., 2011). Here, TYK2 is linked to Crohn disease.