The YIPF5 expression pattern we observed in human embryonic brain, showing high expression in progenitor and neuronal compartments of the developing cortex in addition to the choroid plexus within the cerebral ventricles, is consistent with YIPF5 playing a role in neural progenitors and/or neurons during development of the cerebral cortex, which is mostly affected by primary microcephaly. The gene discussed is YIPF5; the disease is Primary microcephaly.