In HeLa and CaSki cells, another human cervical cancer cell line, YIPF5 constitutively activated IRE1 and PERK signaling, with YIPF5-depleted cells showing reduced IRE1 phosphorylation, lower PERK mRNA and protein expression, and less PERK phosphorylation and downstream signaling (39). The gene discussed is EIF2AK3; the disease is cervical cancer.