While in a mouse model of diabetes, ACE2 (IB, ab15347) was found upregulated in the liver and pancreas and pancreatic ACE2 activity was also increased (Roca-Ho et al., 2017), scRNA-seq analysis revealed decreased ACE2 mRNA levels in ductal cells of T2D patients compared to controls (Chen et al., 2020; Figure 1). This evidence concerns the gene ACE2 and type 2 diabetes mellitus.