Although limited in the scope (n = 8 healthy, 9 smokers and 10 COPD donors), IHC detection of ACE2 (ab15348) in resected lung tissues supports higher protein expression in COPD, and to a lesser extent in smokers, compared to healthy individuals (Leung et al., 2020). The gene discussed is ACE2; the disease is chronic obstructive pulmonary disease.