In the LCLs derived from individuals with diabetes, FLCN was upregulated in response to glucose to a greater extent in individuals with diabetic retinopathy than in individuals with diabetes without retinopathy (log2FC difference = 0.27, p=2.5×10−3) (Figure 2, Supplementary file 1b, and Figure 4—figure supplement 2). This evidence concerns the gene FLCN and retinal disorder.