FLCN and diabetic retinopathy: We then validated the FLCN association with diabetic retinopathy in a third cohort, the UK Biobank (UKBB) (Supplementary file 1c), and found that the FLCN eSNPs were enriched for association with diabetic retinopathy in the UKBB (π1 = 0.73) (Figure 4—figure supplement 4).