Onset of T1D is modeled by treatment of insulin-secreting cells with proinflammatory cytokines TNF-α, INF-γ, and IL-1β, which leads to decreased insulin release and a loss of Doc2B, an established biomarker for the disease (Aslamy et al., 2018a; Aslamy et al., 2018b). The gene discussed is IL1B; the disease is type 1 diabetes mellitus.