MTOR and coronary artery disorder: 2013). In recent years, several studies suggested that statins have a modulating effect for the regulation of autophagy and apoptosis (Yang et al. 2010; Ghavami et al. 2011). Simvastatin is the first line therapeutic drug for coronary heart disease and atherosclerosis. Researches indicated that simvastatin can also increase autophagy in coronary arterial myocytes by inhibition of major negative autophagy regulator Racl-mammalian target of rapamycin (mTOR), a pivotal AMPK/Akt downstream target (Wei et al. 2013).