Our data suggest thata low-calorie ketogenic diet can be considereda successful strategy and therapeutic option for psoriasis management.IL-2 and IL-1β, together with the concentrations of l-leucine, l-alanine, l-glutamine, l-glutamate,and choline, can be considered promising biomarkers for the earlydiagnosis and correct prognosis of psoriasis patients. This evidence concerns the gene IL1B and psoriasis.