GH1 and obesity due to melanocortin 4 receptor deficiency: Finally, in the univariate analysis with Cox regression model, cholelithiasis (HR 0.270, 95% CI 0.1084–0.674, p = 0.005), obesity (HR 0.282, 95% CI 0.083–0.955, p = 0.043) and high BMI (HR 0.899, 95% CI 0.818–0.989, p = 0.029) before UDCA starting, confirmed to be negative predictors of treatment effectiveness, while higher GH levels assessed before UDCA were a positive predictor (HR 1.081, CI 1.003–1.166, p = 0.043).