In fact, BMI (p = 0.012), triglycerides (p = 0.044), LDL (p = 0.020), non-HDL cholesterol (p = 0.037) levels, obesity rate were significantly lower (p 0.017), whereas GH (p = 0.005) and IGF-I/ULN (0.058) values were higher in the BAE regression group, if compared to patients without BAE regression (Table 4). This evidence concerns the gene IGF1 and obesity due to melanocortin 4 receptor deficiency.