On the other hand, multiple genes from the HDAC pathways were also shortlisted as potential SL partners for TP53 mutation, e.g. HDAC8 in BRCA, HDAC5, HDAC6 and HDAC7 in BLCA, HDAC2 and HDAC6 in lower grade glioma (LGG), HDAC4 in LUAD. The gene discussed is TP53; the disease is central nervous system cancer.