Concurrent loss of Tet2 and Bcor in murine hematopoietic compartment leads to lethal MDS development in vivo.28 In addition, simultaneous loss of Tet2 and expression of Sf3b1K700E or cKitD814V in murine hematopoietic cells induces MDS or myeloproliferative neoplasm (MPN) like disease in vivo,29,30 suggesting that multiple combinations of leukemic disease alleles found in our MDS/AML model have driven initiation of MDS and leukemic transformation in the original case. The gene discussed is TET2; the disease is myelodysplastic syndrome.