CD8A and anti-neutrophil cytoplasmic antibody-associated vasculitis: A first study of transcriptome profiling defined a transcriptional signature of CD8 T-cell exhaustion, associated with prediction of better prognosis in AAV, along with other autoimmune diseases.4 In order to utilise this method to explain disease mechanisms and strengthen standard classification criteria, we analysed whole blood transcriptome of 42 AAV patients (with MPA, GPA or EGPA) and 11 healthy individuals.