FOXO1 and systemic lupus erythematosus: Hritzo Ahye MK and Golding A identified such a phenotype, based on the localisation of FOXO1 transcription factor.37 FOXO1, which is involved in B cell development,38 translocates from the nucleus to the cytoplasm (presumably in an AKT-dependent manner) in response to BCR ligation, and thus gets inactivated.39 In SLE, a cytoplasmic FOXO1 double negative B cell population – termed CytoFOX DN B cells – expands in patients, with the expansion being more pronounced in African-American females.37 In fact, the DN B cells of the patients are enriched in CytoFOX DNs.