NR2E3 and retinitis pigmentosa: The novel mice models may also provide an instrumental tool for evaluating disease progression and therapeutic efficacy since the ∆E8 mutant is the first model of Retinitis Pigmentosa caused by mutations in Nr2e3. From the technical point of view, other researchers may be interested in comparing methods for minimizing potential off-target effects of the full Cas9, or in the efficiency of the Cas9 D10A nickase for the generation of medium-large size deletions.