The results of the adjustment for conventional clinical patterns by univariate Cox regression analysis, including gender, age, ALT, cirrhosis, main tumor size, multinodular, BCLC stage, TNM stage, CLIP stage, AVR-CC, AFP, and risk score, indicated that TNM stage, BCLC stage, and risk score acted as independent prognostic factors for RFS of HCC patients. This evidence concerns the gene AFP and hepatocellular carcinoma.