The results of the adjustment for conventional clinical patterns by univariate Cox regression analysis, including gender, age, ALT, cirrhosis, main tumor size, multinodular, BCLC stage, TNM stage, CLIP stage, AVR-CC, AFP, and risk score, indicated that TNM stage, BCLC stage, and risk score acted as independent prognostic factors for RFS of HCC patients. The gene discussed is AFP; the disease is Cirrhosis.