Similarly, higher expression of HDAC1 and HDAC3 are associated with poor prognosis in lung adenocarcinoma, while reduced expression of class II HDAC (specifically HDAC5, 6, and 10) is associated with poor prognosis in NSCLC (Osada et al., 2004; Minamiya et al., 2010, 2011). This evidence concerns the gene HDAC9 and non-small cell lung carcinoma.