PFN1 and malignant peripheral nerve sheath tumor: When applying both PTPRS and profilin 1 as classification parameters in MPNST patients, the longest overall survival was detected in PTPRS high expression and profilin 1 low expression MPNST patients, while the shortest overall survival was observed in PTPRS low expression and profilin 1 high expression group (p = 0.0199, Figure 5D).