Importantly, the Malpighian tubules are vital for detoxication (Chahine and O’Donnell, 2011), and a recent study presented that CG4928 is linked to manganese toxicity and might be involved in the process of detoxification (Mohr et al., 2018), and the human UNC93A was recently identified as a metabolite-associated locus in chronic kidney disease patients (Schlosser et al., 2020). This evidence concerns the gene UNC93A and chronic kidney disease.