Then, several well-known tumor suppressor genes related to stem cells in gastric cancer, such as EphB3, E-cadherin, STAT3, P16, PTEN, GSDME, and GSDMB were selected as target genes for the following analysis (Fujii and Ochiai, 2008; Pan et al., 2016; Chen et al., 2017; Gan et al., 2018; Ni et al., 2018; Xu et al., 2018; Li et al., 2020). Here, PTEN is linked to gastric cancer.