CDKN2A and neoplasm: Moreover, the tumor suppressor locus Ink4a/Arf, E-cadherin, FOXC1, and components of DNA damage repair pathways, which can be silenced by EZH2, have been shown to contribute to oncogenesis (Bruggeman et al., 2005; Cao et al., 2008; Chang et al., 2011; Du et al., 2012).