Twenty-two percent of diffuse large cell B-cell lymphomas and 7–12% of follicular lymphomas show recurrent heterozygous point mutations at tyrosine 641 (Y641) within the C-terminal catalytic SET domain of EZH2 (Morin et al., 2010; Bödör et al., 2011). Here, EZH2 is linked to diffuse large B-cell lymphoma.