As a core member of the Polycomb group (PcG) protein family, EZH2 plays an important role in stem cell maintenance and tumor development (Chang and Hung, 2012) and is overexpressed in various cancers (Varambally et al., 2002; Kleer et al., 2003; Bachmann et al., 2006; Saramaki et al., 2006; Bryant et al., 2007). The gene discussed is EZH2; the disease is cancer.