EZH2 and neoplasm: In several tumor models, the knockdown of EZH2 protein expression results in proliferation inhibition, further demonstrating that EZH2 is a bona fide oncogene (Varambally et al., 2002; Kleer et al., 2003; Karanikolas et al., 2009; Li et al., 2009; Eskander et al., 2013; Nakagawa et al., 2013; Katona et al., 2014; Tang et al., 2014).