Moreover, due to the function of PRC2 in maintaining transcriptional gene silencing, EZH2 mutations always exert both oncogenic and tumor-suppressive effects and both gain-of-function and loss-of-function behavior (Di Croce and Helin, 2013; Comet et al., 2016; Kim and Roberts, 2016). The gene discussed is EZH2; the disease is neoplasm.