For PCa, dysregulated FA metabolism, which is mechanistically linked to aberrant AR and/or SREBP signaling (49, 144), has multiple candidate factors for pharmacological inhibition, including SREBP (fatostatin) (145), acetyl-CoA carboxylase (ND-646, GS-0976) (146, 147), and SCD1 (Merck Frosst Cpd 3) (148). The gene discussed is AR; the disease is posterior cortical atrophy.