CD274 and neoplasm: The researchers showed that the lesions are enriched in a variety of inhibitory cells, such as programmed cell death-ligand 1 (PD-L1) hiCD64hiCD14hiPPARγhi IL-6hi macrophages, CD1c+DC, CD39hiCD38hiPD1hiCTLAhi T regular cell (Treg), and exhausted T cells, and depleted of cells that can effectively exert anti-tumor effector functions, such as CD141+ dendritic cell (DC), CD16+ monocytes, NK cells, and granzyme B+ effector cells.