One of the main findings of this study was that in vitro, sapitinib significantly increased the efficacy of the anti-cancer drugs paclitaxel and doxorubicin in SW620/Ad300 colon cancer cells and ABCB1 transfected HEK293/ABCB1 cells, which overexpress ABCB1 transporter. The gene discussed is ABCB1; the disease is malignant colon neoplasm.