ABCB1 and malignant colon neoplasm: In this study, we conducted in vitro experiments to determine if sapitinib reverses MDR to paclitaxel and doxorubicin in the human colon cancer cell line, SW620/Ad300, which overexpresses the ABCB1 transporter and in HEK293 cells transfected with the ABCB1 gene which overexpress the ABCB1 transporter.