CD274 and non-small cell lung carcinoma: Previous research reported an objective response rate (ORR) ranging from 14 to 20% in NSCLC patients who were treated with single-agent ICIs as second-line therapy before programmed death-ligand 1 (PD-L1) biomarker selection, with a median overall survival (OS) ranging from 10 to 12 months (3–6).