Characterized by the high expressions of arginase-1, macrophage scavenger receptor 1 (CD204), and mannose receptor (CD206), M2 macrophages produce high levels of IL-10, vascular endothelial growth factor (VEGF), and matrix metalloproteinase, which can contribute to an anti-inflammatory response and pro-tumorigenic functions, such as tumor growth, survival and angiogenesis. Here, VEGFA is linked to neoplasm.