Bcl-xl has also been shown to have an apoptosis-independent function in metastasis in pancreatic neuroendocrine tumor and breast cancer cell lines via nuclear promotion of epithelial-mesenchymal transition, migration, invasion, and stemness and in chemoresistance via RAS interaction and influence on EMT and regulation of cancer-initiating cell (CICs) (42, 43). This evidence concerns the gene BCL2L1 and pancreatic neuroendocrine tumor.