Although the splicing change of BCL2L1 is small between hnRNPB1 siRNA transfected HCT116 colon cancer cells when compared to the untransfected cell, the ratio of Bcl-xs/Bcl-xl could be critical for cell survival as evident by increased caspase-3-cleavage and decreased cell viability in hnRNPB1 siRNA transfected cells. The gene discussed is BCL2L1; the disease is malignant colon neoplasm.