CASP3 and cancer: Quantification of the images show a significant dose dependent increase in caspase-3-cleavage/cell number with up to a 12-fold increase in caspase-3-cleavage in HCT116 cancer cells treated with the plant extract when compared to the untreated cells (p < 0.0001 at 140 μg/ml) and up to a 2-fold increase in both OE33 and KYSE77 (Supplementary Figure 1).