Our findings on splicing of hnRNPA2B1 and BCL2L1 in HCT116 colon cancer cells and OE33 and KYSE70 esophageal cancer cells treated with the crude extract of C. orbiculata clearly suggests that C. orbiculata switches splicing of hnRNPA2B1, which in turn regulates splicing of BCLX to induce apoptosis in HCT116 colon cancer cells. The gene discussed is BCL2L1; the disease is malignant colon neoplasm.