The effects of C. orbiculata was similar to those of pladienolide B (14, 15) in that, just like C. orbiculata, pladienolide B switches splicing of hnRNPA2B1 and BCL2L1 to induce apoptosis in HCT116 colon cancer cells (Figure 4). Here, BCL2L1 is linked to malignant colon neoplasm.