RT-PCR revealed that knockdown of hnRNPB1 can increase Bcl-xs in colon cancer cells resulting in an increase in caspase-3 cleavage and a decrease in cell viability, suggesting that hnRNPB1 modulates splicing of BCL2L1 and is functionally involved in cell proliferation in HCT116 colon cancer cells. This evidence concerns the gene CASP3 and colonic neoplasm.