To confirm this, we showed that over-expression of hnRNPB1 blocks the effect of C. orbiculata extract in HCT116 colon cancer cells, indicating that the effect was hnRNP splicing dependent, and that hnRNPA2/B1 splicing is the target for the active ingredient(s) in C. orbiculata extract. Here, HNRNPA2B1 is linked to colonic neoplasm.