RT-PCR revealed that knockdown of hnRNPB1 can increase Bcl-xs in colon cancer cells resulting in an increase in caspase-3 cleavage and a decrease in cell viability, suggesting that hnRNPB1 modulates splicing of BCL2L1 and is functionally involved in cell proliferation in HCT116 colon cancer cells. The gene discussed is BCL2L1; the disease is colonic neoplasm.