KDR and renal cell carcinoma: Cabozantinib is a multi-tyrosine kinase inhibitor primarily targeting tyrosine-protein kinase Met (c-MET), vascular endothelial growth factor receptor 2 (VEGFR2), and tyrosine kinase receptors AXL and RET, which was initially approved to treat medullary thyroid cancer or advanced renal cell carcinoma (RCC) (11, 12).