Various p53 isoforms abnormal expression was also evidenced in breast cancer, ovarian cancer, colon carcinoma, head and neck tumors, glioblastoma, melanoma, renal cell carcinoma, lung cancer, and acute myeloid leukemia, hepatic cholangiocarcinoma, and acute myeloid leukemia [37-39]. The gene discussed is TP53; the disease is acute myeloid leukemia.