With the goal of classifying CRC patients based on the dynamics between T-cell activation, exclusion, and dysfunction, we profiled the expression of CD8A, CD8B, GZMA, GZMB, and PRF1 for T-cell activation, TIDE developed by Jiang et al. [2] to estimate TAM.M2, MDSC, and CAF signatures, as well as PD-L1 gene expression to represent T-cell dysfunction in two independent cohorts. Here, CD274 is linked to colorectal carcinoma.