CMS1 was characterized by the highest expression of genes specific for cytotoxic lymphocytes and PD-L1/PD-L2 genes and CMS4 by massive tumor infiltration by both CD8+ T-cells and CAF [13], which are consist with the features of the immune-dysfunctional cluster with high T-cell infiltration, T-cell dysfunction, and CAF. This evidence concerns the gene CD8A and neoplasm.