INS and diabetes mellitus: Importantly, DANCR has been associated with diabetes mellitus via the cell metabolism regulator Insulin-like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2), which regulates DANCR’s expression and stability (147); additionally, DANCR regulates the PI3K/AKT pathway, which affects insulin homeostasis, and is also involved in inflammatory and cholinergic function (148–150).