It was a surprise when in 2008, Chung et al. observed that in some patients who developed a severe anaphylaxis following even the very first administration of the new epidermal growth factor receptor (EGFR)-antibody cetuximab, the relevant epitope turned out to be alpha-gal and that affected patients seemed to have preformed IgE directed to it (37). The gene discussed is EGFR; the disease is anaphylaxis.