TNF and Sepsis: When compared to sham-operated mice, WT mice subjected to CLP sepsis showed a significant increase in the serum levels of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β, the anti-inflammatory cytokine IL-10, neutrophils chemoattractant chemokines (KC & ENA-78), monocyte chemoattractant chemokines (MCP-1, MIP-1α, and MIP-1β) and G-CSF.