In advanced solid tumor (as NSCLC, renal cell carcinoma, bladder cancer, squamous cell carcinoma of the head and neck and melanoma) the trial NCT01968109 is evaluating the efficacy of Relatlimab as a monotherapy or in combination with Nivolumab (an anti-PD-1 antibody). Here, PDCD1 is linked to urinary bladder carcinoma.