As numbers of neutrophils in saliva possibly reflects the emergency granulopoiesis (18) and the presence of tumor-derived chemoattractants in saliva, including CXCL-8 (118, 119), may additionally impact the total amount of oPMN, their numbers in saliva might be considered easily accessible biomarker for tumor progression and prognosis of the disease. This evidence concerns the gene CXCL8 and neoplasm.