While in a DTH-model based on Th1 cell transfer before challenge we observed only a minor improvement of the tolerogenic potential already shown by the native peptide upon use of the PEGylated conjugate, we found, in a forthcoming study, that vaccination with PEGylated myelin-derived peptide MOG is much more effective in preventing disease in a mouse EAE-model for human multiple sclerosis (35). Here, MOG is linked to multiple sclerosis.