It has been found that the FMDV structural protein VP1 can interact with soluble resistance-related calcium binding protein (sorcin) to inhibit type I IFN production induced by SeV or TNF-α, and the interaction between FMDV VP1 and sorcin can also disrupt the signal transduction of NF-κB, leading to persistent FMDV infection of the host (Li et al., 2013); however, further study is still required to determine its specific mechanism. This evidence concerns the gene SRI and infection.