On the other hand, evidence collected so far in women with chronic hyperprolactinemia did not clearly document an increased prevalence of uterine neoplastic diseases, and studies specifically focusing on uterine PRL synthesis and release following treatment with dopamine agonists are required to better elucidate the burden and the role of peripheral PRL and dopamine agonists therapy on uterine malignancies. The gene discussed is PRL; the disease is hyperprolactinemia.