In an intricate process inside the bone, tumor cells secrete osteoclastogenic factors (e.g., IL-1, IL-6, IL-11, PDGF, MIP1α, TNF, M-CFS, RANKL, and PTHrP) that help stimulate the recruitment and activity of osteoclast, key players in the formation of osteolytic lesions (17). This evidence concerns the gene TNFSF11 and neoplasm.