For that purpose, the Genetic Markers for Osteoporosis (GENOMOS) consortium was created in order to study “classical” candidate gene polymorphisms such as ESR1, COL1A1, VDR, TGFbeta and LRP5 in relation to osteoporosis-related outcomes in a well-powered setting of subjects drawn from several study populations around the globe. The gene discussed is LRP5; the disease is osteoporosis.