There are two mechanisms related to acute post-exercise Leukocytosis: (1) increased cardiac output and, consequently, blood flow in the pulmonary, hepatic and splenic vascular bed, which induces, through shear stress, leukocyte demargination; and (2) increase in the expression of β-2 adrenergic and glucocorticoids receptors in leukocytes, thus increasing their activation in response to adrenaline and glucocorticoids during exercise [13]. Here, NR3C1 is linked to Increased total leukocyte count.