Umbilical cord blood is a rich source of hematopoietic stem cells, and umbilical cord blood transplantation (UCBT) has been used for treatment of malignant and nonmalignant diseases to re-establishment of the hematopoietic system and correct immunodeficiency (Frassoni et al., 2003; Munoz et al., 2014)._ENREF_5 Previous studies have shown that UCBT with reduced-intensity conditioning has represented a curable treatment for patients with IL10RA-associated immune deficiency, making it a potential treatment for IBD (Uhlig and Muise, 2017; Ye et al., 2017; Peng et al., 2018; Zheng et al., 2019). This evidence concerns the gene IL10RA and Immunodeficiency.