RELA and gestational diabetes: Previous reports showed that placentae of GDM mother patients and nascent nephron of hyperglycemic patients displayed a remarkable overexpression of p65 and relative inflammatory factors (Chen et al., 2011) and p65 has been recognized as a central molecule to regulate the expression of oxidative stress- and inflammatory-responsive genes in gestational tissues, including the placenta and umbilical cord blood (Barnes and Karin, 1997; Haddad, 2002; Lappas et al., 2002), indicative of the pivotal role of p65.