Although insulin has been seemed as the gold standard for hyperglycemia treatment during pregnancy (Park et al., 2015), in this study, we demonstrated that MET promoted angiogenesis against GDM-induced impairment via enhancing Nrf2 expression and downregulating transcriptional factor p65, which could provide a new theoretical basis for the therapy of gestational diabetes, not only via controlling blood glucose levels, but also via improving endothelial dysfunction. This evidence concerns the gene INS and endothelial dysfunction.