NFE2L2 and endothelial dysfunction: Nuclear factor erythroid 2-related factor 2 (Nrf2) has been implicated to play crucial roles in the control of inflammation, and is a master modulator of redox homeostasis via accommodation action among a battery of cytoprotective genes (Innamorato et al., 2009; Jazwa and Cuadrado, 2010; Bryan et al., 2013) to protect against diabetes-induced endothelial dysfunction (Sharma et al., 2017).